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Daniela Francesca Angelini

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Articles

CD99 as a novel therapeutic target on leukemic progenitor cells in FLT3-ITDmut AML - Leukemia

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By Francesco Marchesi, Raffaele Palmieri, Adriano Venditti, Maria Teresa Voso, Daniela Francesca Angelini, Nelida Ines Noguera, Marco De Bardi, Francesco Fazi, Marco Pieraccioli, Luca Battistini
| Nature Verified
Acute Myeloid Leukemia with FLT3 internal tandem duplication mutations (FLT3-ITDmut AML) is an aggressive leukemia characterized by heterogeneous genetic landscape [1]. Despite significant advances in AML therapy, the relapse rate remains high, due to the emergence of resistant clones, possibly involving leukemic stem cells (LSCs) [2]. This highlights the unmet need for deeper understanding of the molecular and immunophenotypic landscape of LSCs in FLT3-ITDmut AML.
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