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Articles by Daniela Mestre
Machine learning using PROFUND components for 30-day readmission prediction in multimorbid patients: a prospective multicentre study
Abstract Early hospital readmission in multimorbid patients remains a major clinical challenge. Although risk stratification tools are widely used, predictive performance is often limited. The PROFUND index captures frailty, functional dependence, and social vulnerability, but its role in predicting 30-day readmission is unclear. In this prospective multicentre cohort study, multimorbid patients admitted to Internal Medicine and Geriatrics departments were followed after discharge.
Validation of Basque “Test of Adherence to Inhalers” in asthma and
Back to Journals » Patient Preference and Adherence » Volume 19 Authors Mestre D , Orive M, Gascón M, Bilbao-González A, González-Hernández N, Dorado-Arenas S, Aramburu A, Quintana JM Received 18 June 2025 Accepted for publication 6 November 2025 Published 12 December 2025 Volume 2025:19 Pages 4051—4061 DOI https://doi.org/10.2147/PPA.S548109 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Ramón Morillo-Verdugo...
Gibel gantzatsu ez-alkoholikotik eta harekin lotutako minbizitik babesten du E2F1 eta E2F2 inhibitzeak
Lehenengo argitaratze data: 2021/08/04 UPV/EHUko Lipids&Liver ikerketa-taldea buru duen nazioarteko ikerketa batean, zeina Cancer Research aldizkari entzutetsuan argitaratu baitute, frogatu dute gibelean E2F1 edo E2F2 proteinak inhibitzean babestu egiten dela obesitateari lotutako gibel gantzatsu ez-alkoholikoa garatzetik eta minbizi bihurtzetik. Beraz, patologia hori tratatzeko bi itu terapeutiko izan daitezke.
La inhibición de E2F1 y E2F2 protege del hígado graso no alcohólico y del cáncer hepático asociado
Fecha de primera publicación: 04/08/2021 Un estudio internacional liderado por el grupo de investigación Lipids&Liver de la UPV/EHU, y publicado en la prestigiosa revista Cancer Research, ha demostrado que la inhibición de cualquiera de las proteínas E2F1 o E2F2 en hígado protege frente al desarrollo de hígado graso no alcohólico asociado a obesidad y su progresión a cáncer. Se trata, por tanto, de dos potenciales dianas terapéuticas para el tratamiento de esta patología.
E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment
Metabolism and Chemical Biology Francisco González-Romero, Daniela Mestre, Igor Aurrekoetxea, Colm J. O'Rourke, Jesper B. Andersen, Ashwin Woodhoo, Miguel Tamayo-Caro, Marta Varela-Rey, Marta Palomo-Irigoyen, Beatriz Gómez-Santos, Diego Sáenz de Urturi, Maitane Núñez-García, Juan L. García-Rodríguez, Larraitz Fernández-Ares, Xabier Buqué, Ainhoa Iglesias-Ara, Irantzu Bernales, Virginia Gutierrez De Juan, Teresa C.
E2F1 and E2F2-mediated repression of CPT2 establishes a lipid-rich tumor-promoting environment
Research Article Francisco Gonzalez-Romero, Daniela Mestre, Igor Aurrekoetxea, Colm J. O'Rourke, Jesper B. Andersen, Ashwin Woodhoo, Miguel Tamayo-Caro, Marta Varela Rey, Marta Palomo-Irigoyen, Beatriz Gómez-Santos, Diego Sáenz de Urturi, Maitane Núñez-García, Juan L. García-Rodríguez, Larraitz Fernández-Ares, Xabier Buqué, Ainhoa Iglesias-Ara, Irantzu Bernales, Virginia Gutierrez De Juan, Teresa C. Delgado, Naroa Goikoetxea-Usandizaga, Richard Lee, Sanjay Bhanot, Igotz Delgado, Maria J.
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