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Engaging families with experience of neonatal hypoxic ischemic encephalopathy: a call to action
We acknowledge that there are many excellent neonatal units and health care professionals. We focus on variations from excellence because that is how to address family concerns most directly. The clinical context is central to how families view research. Exposure to suboptimal care conditions how families respond to approaches about research and their contributions to research, Box 1.
Microglial depletion worsens lesion in female but not male C57BL/6J mice after P10 hypoxia-ischemia
Abstract Background: Rodent models for perinatal hypoxic ischemic (HI) encephalopathy have reported sex differences such as the same injury causing larger lesions in the brains of males compared to females. Microglia, the resident immune cells of the brain that have sex-dependent developmental trajectories and gene expression patterns, likely play a different role in females and males following HI.
Microglial depletion worsens lesion in female but not male C57BL/6J mice after P10 hypoxia-ischemia
Abstract Background: Rodent models for perinatal hypoxic ischemic (HI) encephalopathy have reported sex differences such as males having larger brain lesions than females after the same injury. Microglia, the resident immune cells of the brain that have distinct developmental trajectories and gene expression patterns by sex, likely play a different role in males and females following HI.
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