Danilo Monteiro Ribeiro

Abstract BRCA1 and BRCA2 are tumor suppressor genes essential for DNA repair. Mutations in these genes significantly increase breast (BC) and ovarian cancer (OC) risk, with BRCA1-positive facing a 70% BC and 40% OC lifetime risk. While guidelines for BRCA-positive are well established, recommendations for BC surveillance in BRCA-patients already diagnosed with OC remain limited. This meta-analysis evaluates BC risk post-OC in BRCA-mutated women.

ABSTRACT Introduction Cenobamate (CNB) is an anti-seizure medication (ASM)utilized for drug-resistant focal-onset seizures, which are difficult to managewith usual agents. Previous studies demonstrated that it can be effective inpatients with refractory epilepsy. Methods The MEDLINE, Cochrane, and Scopus databases weresystematically searched up to 24 October 2024. A Random-effects model wasemployed to compute the Mean Difference (MD) and the Risk Ratio (RR) with 95%Confidence Intervals (CI).