Danitra J Parker

Post-print Animals, Proteasome Endopeptidase Complex, Mice, Cognitive Dysfunction, Aging, Male, Hippocampus, Mice, Inbred C57BL, aging brain, mice, proteasome, proteostasis yes Parker, Danitra; Davidson, Kanisa; Osmulski, Pawel A; et al., "Proteasome Augmentation Mitigates Age-Related Cognitive Decline in Mice" (2025). Faculty, Staff and Student Publications. 6420. https://digitalcommons.library.tmc.edu/uthgsbs_docs/6420

1 Introduction Declines in proteasome function are a robust feature of aging reported in a wide range of tissues in mice (Bardag-Gorce et al. 1999; Keller, Hanni, and Markesbery 2000; Rodriguez, Gaczynska, and Osmulski 2010), including the nervous system (Keller, Hanni, and Markesbery 2000). Similar declines are observed in the heads of fruit flies (Munkacsy et al. 2019) and the brains of killifish (Kelmer Sacramento et al. 2020).

Abstract Background: Alzheimers Disease (AD) is the leading cause of dementia globally, affecting around 50 million people and marked by cognitive decline and the accumulation of β-amyloid plaques and hyperphosphorylated tau. The limited treatment options and numerous failed clinical trials targeting β-amyloid (Aβ) highlight the need for novel approaches. Lowered proteasome activity is a consistent feature in AD, particularly in the hippocampus.