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Danlu Jiang

As seen in: Cell Press
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Articles by Danlu Jiang

Gasdermin-D-mediated epithelial-immune circuit synchronizes nutrient absorption and host defense in the small intestine

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By Qianzhou Yu, Danlu Jiang, Tianming Zhao, Jian Zhang, Dehang Yang, Ruya Sun, WeiWei Yu, Zhen Wang, Sheng Chen, Mobai Li, TianYi Hu, Qiqi Deng, Xiaoyang Lu, Yidong Yang, Xue Zhang, Zhexu Chi, Di Wang, Yuelin Guan, Mengfei Chang, Liheng Du
| Cell Press Verified
Keywords GSDMD the small intestine enterocyte brush border assembly intraepithelial γδ T lymphocytes nutrient absorption host defense nutritional imbalance feeding pattern enteritis Get full text access Log in, subscribe or purchase for full access. References 1. Turner, J.R. Intestinal mucosal barrier function in health and disease Nat. Rev. Immunol. 2009; 9:799-809 2. Ko, C.W. ∙ Qu, J. ∙ Black, D.D. ... Regulation of intestinal lipid metabolism: current concepts and relevance to disease Nat. Rev.
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Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages

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By Chuansheng Guo, P. r., Zhexu Chi, Danlu Jiang
| Cell Press Verified
Cholesterol metabolism has been linked to immune functions, but the mechanisms by which cholesterol biosynthetic signaling orchestrates inflammasome activation remain unclear. Here, we have shown that NLRP3 inflammasome activation is integrated with the maturation of cholesterol master transcription factor SREBP2. Importantly, SCAP-SREBP2 complex endoplasmic reticulum-to-Golgi translocation was required for optimal activation of the NLRP3 inflammasome both in vitro and in vivo.
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