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Danny Chan

Hong Kong
As seen in: Nature, Wiley Online Library, arXiv, BMJ Open, Frontiers, MDPI, South China Morning Post, Science Magazine, Cell Metabolism, Stem Cell Reports and
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Articles

Body-wide multi-omic counteraction of aging with GLP-1R agonism

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By Junzhe Huang, Andrew Kwok, Bonaventure Ip, Lok Yi Tung, Roy Chan, Danny Chan, Ziyu Wang, Xianyi Zheng, Michelle Lo, Zhongqi Li, Nenghan Lin, Manyu Wang, Leo Yan, William Wu, Kim Hei-Man Chow, Wei-Jye Lin, Yamei Tang, Yun Zhang, Weihong Song, Billy Wai-Lung Ng, Thomas W. Leung, Vincent C.T. Mok, Ho Ko
| Cell Metabolism Verified
Main text (Cell Metabolism 37, 2362–2380.e1–e8; December 2, 2025) Following publication, Steve Horvath and colleagues at the Clock Foundation alerted us to a platemap error in the DNA methylation (DNAm) data. Our investigation pinpointed the potential source of this error. We provided samples on 96-well plates in a row-wise orientation instead of the column-wise orientation specified in the Clock Foundation’s protocol.
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Genome-edited safe and immune-evasive human pluripotent cells: Potential solution for allogeneic therapies

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By Vivian Tam, Mengxia Zhu, Ting Mei, Janette Siu-Yin Kwok, Eric D. Jong, Jean Tang, Andras Nagy Verified, Danny Chan, Patrick Chu
| Stem Cell Reports Verified
ArticleOnline now102850Open access Affiliations & Notes 1School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China 2Division of Transplantation & Immunogenetics, Department of Pathology, Queen Mary Hospital, Hong Kong SAR, China 3Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada 4Department of Physiology, University of Toronto, Toronto, ON, Canada 5Department of Obstetrics & Gynaecology and Institute of...
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Body-wide multi-omic counteraction of aging with GLP-1R agonism

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By Junzhe Huang, Andrew Kwok, Bonaventure Ip, Lok Yi Tung, Roy Chan, Danny Chan, Ziyu Wang, Xianyi Zheng, Michelle Lo, Zhongqi Li, Manyu Wang, Leo Yan, William Wu, Kim Hei-Man Chow, Wei-Jye Lin, Yamei Tang, Yun Zhang, Weihong Song, Billy Wai-Lung Ng, Thomas W. Leung, Vincent C.T. Mok, Ho Ko, Nenghan Lin
| Cell Metabolism Verified
Keywords aging GLP-1R agonist multi-omics mTOR inhibition brain-body interaction exenatide rapamycin Introduction Aging is a complex process involving diverse cellular and molecular alterations across all body systems, resulting in progressive functional decline. Discovering effective strategies to counteract aging-associated changes is a significant scientific pursuit with profound societal implications, given the potential to improve overall well-being and extend healthy lifespan.
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