Daria Barwinska
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Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules
Abstract The organizational principles of nephronal segments are based on anatomical and physiological attributes that are linked to the homeostatic functions of the kidney. Recent molecular approaches have uncovered layers of deeper signatures and states in tubular cells that arise at various time points on the disease trajectory.
Integration of spatial multiplexed protein imaging and transcriptomics in the human kidney tracks the regenerative potential timeline of proximal tubules
Abstract The organizational principles of nephronal segments are based on longstanding anatomical and physiological attributes that are closely linked to the homeostatic functions of the kidney. Novel molecular approaches have recently uncovered layers of deeper signatures and states in tubular cells that arise at various timepoints on the spectrum between health and disease.
Acute kidney injury results in long-term alterations of kidney lymphatics in mice
Acute kidney injury (AKI) is a common and serious clinical problem associated with significant morbidity and healthcare costs (1–4). Even patients who regain kidney function face an increased risk for developing long-term sequelae, including repeat incidences of AKI (5–8) and progression to chronic kidney disease (CKD) (9–13).
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