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Darianna Colina on Muck Rack

Darianna Colina

As seen in: BioRxiv
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Articles

Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations in vitro and in vivo

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By Tina Ye, Azmain Alamgir, Cara M Robertus, Darianna Colina
| BioRxiv
Abstract Aberrant activation of Wnt signaling results in unregulated accumulation of cytosolic β-catenin, which subsequently enters the nucleus and promotes transcription of genes that contribute to cellular proliferation and malignancy. Here, we sought to eliminate pathogenic β-catenin from the cytosol using designer ubiquibodies (uAbs), chimeric proteins composed of an E3 ubiquitin ligase and a target-binding domain that redirect intracellular proteins to the proteasome for degradation.
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