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Darius Baradaran on Muck Rack

Darius Baradaran

As seen in: ACS Publications
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Articles

Redox-Responsive Disulfide Cyclic Peptides: A New Strategy for siRNA Delivery

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By Dindyal Mandal, Sandeep Lohan, Parvin Mandipoor, Darius Baradaran
| ACS Publications
RNA interference (RNAi) is a powerful tool capable of targeting virtually any protein without time-consuming and expensive drug development studies. However, due to obstacles facing efficient and safe delivery, RNAi-based therapeutic approach remains a challenge. Herein, we have designed and synthesized a number of disulfide-constraining cyclic and hybrid peptides using tryptophan and arginine residues.
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