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Dariusz Bartosik

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Large extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome

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By Jakub Czarnecki, Morgan Lambérioux, Ole Skovgaard, Amaury Bignaud, Najwa Taib, Theophile Niault, Jasmin Ostermayer, Pascale Bourhy, Julia Bos, Romain Koszul, Martial Marbouty, Didier Mazel, Marie-Eve Val, Elvira Krakowska, Dariusz Bartosik
| Nature Verified
Abstract Bacterial genomes frequently harbor extrachromosomal replicons (ERs) that promote genome plasticity and adaptation, ranging from small plasmids to chromosome-scale replicons. In a few model organisms, including Vibrio cholerae and Agrobacterium tumefaciens, large ERs are coordinated with chromosome replication and cell-cycle organization by specific molecular mechanisms. Whether this applies broadly across bacteria remains unknown.
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