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Results To systematically generate monoclonal antibodies that selectively target pathological α-syn fibrils, we established a multiplex screening platform comprising immunization, high-throughput binding assays, and functional validation in neuronal systems (Figure 1A). This resource-oriented platform was designed not only to isolate functional anti-α-syn antibodies but also to provide a generalizable workflow applicable to other amyloid pathologies.
Keywords gastrointestinal cancers colorectal cancer CDH17 ADC multidrug resistance Introduction Gastrointestinal (GI) cancers, including liver, gastric, pancreatic, neuroendocrine tumor (NET), and, the most prevalent, colorectal cancers, are among the leading causes of cancer-related mortality globally.
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