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David Barata

As seen in: Nature
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Articles

Next-generation osteosarcoma models for precision medicine

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By Mohamed Saqawa, Marta Lourenço, Claire Villette, David Barata, Silvia Panseri, Diana Pacheco, Nuno Alves Verified, Paula Faria, Liesbet Geris, Carlos Mota Verified, Monica Montesi, Tatiana Patricio, Miguel Vieira Coelho, Lorenzo Apolloni, A. S. Silva-Barroso, Rafaela Seabra, Bernard Staumont
| Nature Verified
Abstract Osteosarcoma (OS) is a highly aggressive bone malignancy that predominantly affects adolescents and young adults. Despite the progress in conventional treatment approaches, such as surgery and chemotherapy, patient outcomes remain poor due to OS metastatic potential, chemoresistance and frequent recurrence.
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Microfluidically Aligned Collagen to Maintain the Phenotype of Tenocytes In Vitro

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By David Barata, Clemens van Blitterswijk, Francesca Giacomini, Zeinab Tahmasebi Birgani
| pericles.pericles-prod.literatumonline.com
Tendon is a highly organized tissue that transmits forces between muscle and bone. The architecture of the extracellular matrix of tendon, predominantly from collagen type I, is important for maintaining tenocyte phenotype and function. Therefore, in repair and regeneration of damaged and diseased tendon tissue, it is crucial to restore the aligned arrangement of the collagen type I fibers of the original matrix.
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A 96-wells fluidic system for high-throughput screenings under laminar high wall shear stress conditions - Microsystems & Nanoengineering

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By Catarina Fonseca, Vania Silverio, David Barata, Susana Cardoso
| Nature Verified
Abstract The ability of endothelial cells to respond to blood flow is fundamental for the correct formation and maintenance of a functional and hierarchically organized vascular network. Defective flow responses, in particular related to high flow conditions, have been associated with atherosclerosis, stroke, arteriovenous malformations, and neurodegenerative diseases. Yet, the molecular mechanisms involved in high flow response are still poorly understood.
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