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David Billing

As seen in: Nature, MDPI, Royal Society of Chemistry, The Drum, Cell Press, Campaign (UK), The Star (Kenya)
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Articles by David Billing

MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness

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By David Billing, Monica Selvaraj, Megan Kelley, Gabriel Matos-Rodrigues, Benton Bailey, Gang Zhen, Matthew Myers Verified, Alessandra Brambati, Oluchi C. Ezekwenna, Ashley Nichols, Yi-Zhen Jiang, Lucia Wang, Shih-Chun Wang, Marie-Claude Mathieu, Davide Pradella, Elias Rodriguez-Fos, Stephen Morris Verified, Michal Zimmermann, Elsa Callen, Michael Zinda, Andrea Ventura, John Maciejowski, Andrew McPherson, Sohrab P. Shah, André Nussenzweig, Agnel Sfeir, Finnja Becker, Hugo Poirier, Anton George Henssen
| Nature Verified
Abstract Extrachromosomal DNA (ecDNA) comprises megabase-sized circular DNA elements that frequently carry oncogene amplifications, driving aggressive tumour phenotypes, therapeutic resistance and poor clinical outcomes across many cancers1,2,3,4. Although ecDNA is thought to arise from canonical double-strand break repair, the pathways that maintain it remain unclear.
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Non-Structural Carbohydrate Composition of ‘Hass’ Avocado Fruit Is Affected by Maturity, Storage, and Ripening

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By Jeremy J. Burdon, David Billing, Judith Bowen, Helen Boldingh
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Chelsea close in on Boateng, Alaba

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By David Billing
| The Star (Kenya) Verified
In Summary • With Thomas Tuchel now settled at Stamford Bridge, I have learned that Chelsea could offer Alaba a pre-contract arrangement in much the same way they brought Thiago Silva from Paris St-Germain. • If you wonder why Pep Guardiola’s teams are always near to or at the top of any league, you only have to look at one of his training sessions.
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Baggies eyeing Allardyce after showing Bilic the door

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By David Billing
| The Star (Kenya) Verified
As I predicted last weekend, after talking to my contacts in the midlands, I expected West Bromwich Albion manager Slaven Bilic to be sacked on Monday.
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The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection

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By David Billing, Angelo Taglialatela, Michiko Horiguchi, Foon Wu-Baer
| Cell Press Verified
The BRCA1 tumor suppressor preserves genome integrity through both homology-directed repair (HDR) and stalled fork protection (SFP). In vivo, BRCA1 exists as a heterodimer with the BARD1 tumor suppressor, and both proteins harbor a phosphate-binding BRCT domain. Here, we compare mice with mutations that ablate BRCT phospho-recognition by Bard1 ( Bard1 S563F and Bard1 K607A) or Brca1 ( Brca1 S1598F).
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