1 Introduction Oral cavity squamous cell carcinoma (OSCC) is a group of malignancies involving the lip, buccal mucosa, gingiva, alveolar ridge, floor of the mouth, anterior tongue, retromolar trigone, and hard palate [1]. In the United States, the prevalence of OSCC has risen steadily while the age-adjusted incidence rate of OSCC has decreased slightly over time; however, this finding is variable according to sex and other demographic characteristics [2].