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Articles by David Graykowski
Alzheimer’s disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits
Keywords Alzheimer’s disease neurodegeneration cortico-hippocampal circuits cortical layers NMDARs β-amyloid tau synaptic dysfunction memory impairment two-photon calcium imaging Neuropixels Introduction Structured spontaneous activity is a hallmark of the cortico-hippocampal circuits supporting memory-guided cognition.1,2 It arises from recurrent synaptic excitation and balanced inhibition3 and is modulated by synaptic N-methyl-D-aspartate receptors (NMDARs).4,5 In Alzheimer’s disease (AD),...
Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo
Keywords Alzheimer’s disease amyloid-beta Aβ visual cortex parvalbumin interneurons selective vulnerability deep cortical layers neuronal pentraxin 2 GluA4 two-photon Ca2+ imaging Neuropixels Introduction Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) accumulation in the neocortex, preceding neuronal loss and cognitive decline by years to decades.1 Although Aβ plaques and neuronal loss occur across all neocortical layers,2,3 it remains unclear whether specific layers and...
Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons
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Keywords neuronal bursting hippocampus CA1 high molecular weight tau CaV2.3 (R-type) channels Alzheimer’s disease human mouse models extracellular electrophysiology patch-clamp electrophysiology Introduction Alzheimer’s disease (AD) is characterized by the presence of β-amyloid (Aβ) plaques and tau neurofibrillary tangles (NFTs) in patient brains, but it is the burden, spatial extent, and region-specificity of tau pathology that are most closely related to disease-related cognitive impairment.
By Samuel Harris, Robert Ellingford, Jana Hartmann, Debanjan Dasgupta, Rikesh M. Rajani, David Graykowski, Dhanush Sivasankaran, Caitlin Commins, Suraya A. Bond, Fred M. Wolf, David Dupret, Raymond J. Dolan, Arthur Konnerth, Andreas Neef, Bradley T. Hyman, Marc Aurel Busche, Marten Kehring, Noé Quittot, Zhanyun Fan
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Cell Press
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Optogenetic polymerization and assembly of electrically functional polymers for modulation of single-neuron excitability
Abstract Ionic conductivity and membrane capacitance are two foundational parameters that govern neuron excitability. Conventional optogenetics has emerged as a powerful tool to temporarily manipulate membrane ionic conductivity in intact biological systems. However, no analogous method exists for precisely manipulating cell membrane capacitance to enable long-lasting modulation of neuronal excitability.
eNeuro Blog
David Graykowski is currently an undergraduate student in neuroscience at the Department of Health Sciences, DePaul University, Chicago, IL. Neurogenesis persists throughout adulthood in the hippocampus, a brain region involved in memory and learning. Perturbation of adult hippocampal neurogenesis is thought to hamper the recovery of memory observed in Alzheimer’s disease (AD) and other neurological disorders.
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