David J. Griffiths on Muck Rack

David J. Griffiths

England
As seen in: Strange Times (Podcast), Nature
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Articles

Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease - Nature Communications

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By Long Châu, Chen-Hsuin Lee, Christine Tait-Burkard, Sarah Fletcher, Louise Gibbard, J. Kenneth Baillie, David J. Griffiths
| Nature Verified
Abstract Animal models that accurately reflect COVID-19 are vital for understanding mechanisms of disease and advancing development of improved vaccines and therapeutics. Pigs are increasingly recognized as valuable models for human disease due to their genetic, anatomical, physiological, and immunological similarities to humans, and they present a more ethically viable alternative to non-human primates.
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