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Articles

Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction

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By David Larousserie et, Price TJ, Franco-Enzástiga Ú, Patel KJ
| ncbi.nlm.nih.gov
This is a preprint. It has not yet been peer reviewed by a journal. The National Library of Medicine is running a pilot to include preprints that result from research funded by NIH in PMC and PubMed. bioRxiv. Display options Format doi: 10.1101/2023.06.03.543579.
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Pain Ligand-Receptor “Interactome” Revealed

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By Stephani Sutherland, Neerukonda SV, Naik DK, David Larousserie et
| painresearchforum.org
Nociceptive sensory neurons innervate all the tissues of the body. Pain researchers have identified hundreds of receptors in such neurons over the past several decades, and these receptors are specialized to detect a huge variety of stimuli, including chemicals released from other cells. But the field has made little progress in determining the exact drivers of nociceptive signaling – the ligands that activate the receptors – in specific tissues affected during chronic pain states.
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