David Macmillan on Muck Rack

David Macmillan

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BBC Tees Political Reporter. All views contractually forbidden. Occasional darts observations. All spelling errors caused by bad magic.
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Articles

Host metabolism can produce many indoles and phenols independently of the microbiome

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By Jenna E. AbuSalim, Kellen Olszewski, Salma Youssef, Sarah Mitchell, Craig Hunter, Jessica Little, Ashley M. Sidebottom, Jacob Boyer, Steve Knutson, Laith Z. Samarah, Michael R. MacArthur, Alessa Henneberg, Rolf-Peter Ryseck, Christiane A. Opitz, David MacMillan, David Macmillan Verified, Mohamed S. Donia, Eric G. Pamer, Sabrina Imam, Christopher J. Lehmann, Olatoyosi Odenike, Joshua D. Rabinowitz
| Nature Verified
Abstract Indole and phenol metabolites are typically thought to be products of bacterial digestion of tryptophan (indoles) and phenylalanine or tyrosine (phenols). Interest in controlling gut microbial production of these metabolites has continually grown because they have important physiological impacts, with indoles agonizing aryl hydrocarbon receptor signalling and phenols being associated with healthy body weight.
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Piecewise Stereoselective Assembly of Multisubstituted Alkenes Click to copy article link Article link copied!

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By Eli Jones, Robert Martin, David MacMillan, David Macmillan Verified
| dx.doi.org
Multisubstituted alkenes are ubiquitous motifs in pharmaceuticals, natural products, (1) and functional materials and also serve as versatile synthetic building blocks. (2,3) Although classical alkene syntheses, including carbonyl olefination (4) and olefin metathesis, (5) have been reliably used to access disubstituted alkenes, the stereoselective synthesis of tri- and tetrasubstituted alkenes remains challenging.
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Piecewise Stereoselective Assembly of Multisubstituted Alkenes Click to copy article link Article link copied!

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By Eli Jones, Robert Martin, David MacMillan, David Macmillan Verified
| ACS Publications
Multisubstituted alkenes are ubiquitous motifs in pharmaceuticals, natural products, (1) and functional materials and also serve as versatile synthetic building blocks. (2,3) Although classical alkene syntheses, including carbonyl olefination (4) and olefin metathesis, (5) have been reliably used to access disubstituted alkenes, the stereoselective synthesis of tri- and tetrasubstituted alkenes remains challenging.
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