David Melzer
Exeter
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Articles by David Melzer
Radiographically identified vertebral fractures in haemochromatosis-associated HFE C282Y homozygotes in the UK Biobank
The authors have declared no competing interest. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: This research has been conducted using the UK Biobank Resource, under application 14631.
Chondrocalcinosis and the haemochromatosis linked HFE C282Y homozygous variant in the UK Biobank
The authors have declared no competing interest. Lucy R. Banfield, Karen M. Knapp and Luke C. Pilling are supported by the University of Exeter. Janice L Atkins is supported by a National Institute for Health and Care Research (NIHR) Advanced Fellowship (NIHR301844). This study is supported by the National Institute for Health and Care Research (NIHR) Exeter Biomedical Research Centre (BRC).
SLCO1B1 Exome Sequencing and Statin Treatment Response in 64,000 UK Biobank Patients
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Mid‐life leukocyte telomere length and dementia risk: An observational and mendelian randomization study of 435,046 UK Biobank participants
Statistical methods The association between TL and time from baseline to first incident AD/ADRD diagnosis was estimated using a Cox proportional hazards model. Previous studies reported a U-shaped association between TL and risk of AD (Fani et al., 2020) or amnestic mild cognitive impairment (Roberts et al., 2014).
The genetics of human ageing - Nature Reviews Genetics
Authors and Affiliations Medical School, University of Exeter, Exeter, UK David Melzer & Luke C. Pilling School of Medicine, University of Connecticut, Farmington, CT, USA David Melzer & Luke C. Pilling National Institute on Aging, Baltimore, MD, USA Luigi Ferrucci Contributions All authors researched the literature, provided substantial contributions to discussions of the content, and reviewed and/or edited the manuscript before submission. D.M. and L.F. wrote the article. Corresponding author
Life’s Simple 7 likely to be associated with dementia risk reduction in both midlife and older age groups
Janice L Atkins research fellow, João Delgado research fellow, David Melzer professor of epidemiology and public health Atkins Janice L, Delgado João, Melzer David. Life’s Simple 7 likely to be associated with dementia risk reduction in both midlife and older age groups BMJ 2019; 366 :l5491
It's The Most Common Genetic Disease in The Western World, But a Lot of Us Have Never Heard of It
JANICE ATKINS, DAVID MELZER & LUKE PILLING, THE CONVERSATION 19 JAN 2019 Many people have never heard of it, but hereditary haemochromatosis is the most common genetic disease in the Western world, with 250,000 people of European ancestry in the UK affected and a million in the US. The faulty genes responsible cause excessive absorption of iron, which sometimes builds up to toxic levels. We've now shown that these faulty genes cause more damage around the body than previously thought.
Haemochromatosis: disorder that causes body to absorb too much iron from food may be major cause of disease
Many people have never heard of it, but hereditary haemochromatosis is the most common genetic disease in the Western world, with 250,000 people of European ancestry in the UK affected and a million in the US. The faulty genes responsible cause excessive absorption of iron, which sometimes builds up to toxic levels. We’ve now shown that these faulty genes cause more damage around the body than previously thought. But the good news is that the treatment is simple.
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