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David Nettleton

As seen in: MDPI, Drug Metabolism and Disposition (ASPET)
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Articles by David Nettleton

Smart Sensor Control and Monitoring of an Automated Cell Expansion Process

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By David Nettleton, Helena Marti-Soler, Joseph Egan, Núria Marí-Buyé
| MDPI
1. Introduction In this paper, we describe the work related to smart sensors carried out as part of the EU Horizon 2020 project AIDPATH (Artificial Intelligence-driven, Decentralized Production for Advanced Therapies in the Hospital) for the control and monitoring task of the cell expansion process [1].
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Energy Consumption Optimization of a Fluid Bed Dryer in Pharmaceutical Manufacturing Using EDA (Exploratory Data Analysis)

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By David Nettleton, Roberto Barriga, Miquel Romero, Houcine Hassan
| MDPI
Open AccessArticle by Roberto Barriga 1,*, Miquel Romero 1, Houcine Hassan 2 and David Nettleton 3 1 Industrias Farmacéuticas Almirall, Ctra. N-II, Km. 593, 08740 Sant Andreu de la Barca, Spain 2 Departamento de Informática de Sistemas y Computadores, Universitat Politècnica de València, Camino de Vera, No. 14, 46022 Valencia, Spain 3 IRIS Technology Solutions, Ctra. d’Esplugues, 39, 08940 Cornella de Llobregat, Spain * Author to whom correspondence should be addressed.
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Industry Perspective on the Pharmacokinetic and ADME Characterization of Heterobifunctional Protein Degraders

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By Sara Taney Humphreys, Laurie P Volak, Heide Marika Duevel, David Nettleton
| Drug Metabolism and Disposition (ASPET)
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Industry Perspective on the Pharmacokinetic and Absorption, Distribution, Metabolism, and Excretion Characterization of Heterobifunctional Protein Degraders

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By Laurie P Volak, Heide Marika Duevel, Sara Taney Humphreys, David Nettleton
| Drug Metabolism and Disposition (ASPET)
Abstract Targeted protein degraders (TPDs), specifically the bifunctional protein degraders discussed in this manuscript, consist of two linked ligands for a protein of interest and an E3 ligase, resulting in molecules that largely violate accepted physicochemical limits (e.g., Lipinski’s Rule of Five) for oral bioavailability.
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