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Heide Marika Duevel

As seen in: Drug Metabolism and Disposition (ASPET)
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Articles

Industry Perspective on the Pharmacokinetic and ADME Characterization of Heterobifunctional Protein Degraders

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By Sara Taney Humphreys, Laurie P Volak, Heide Marika Duevel, David Nettleton
| Drug Metabolism and Disposition (ASPET)
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Industry Perspective on the Pharmacokinetic and Absorption, Distribution, Metabolism, and Excretion Characterization of Heterobifunctional Protein Degraders

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By Laurie P Volak, Heide Marika Duevel, Sara Taney Humphreys, David Nettleton
| Drug Metabolism and Disposition (ASPET)
Abstract Targeted protein degraders (TPDs), specifically the bifunctional protein degraders discussed in this manuscript, consist of two linked ligands for a protein of interest and an E3 ligase, resulting in molecules that largely violate accepted physicochemical limits (e.g., Lipinski’s Rule of Five) for oral bioavailability.
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