5-HT 5-hydroxytryptamine AE adverse event CGRP calcitonin gene–related peptide CVD cardiovascular disease MBS most bothersome symptom MOH medication overuse headache NMA network meta-analysis NNT number needed to treat PRN as needed QALY quality-adjusted life year INTRODUCTION Acute treatments for migraine aim to relieve pain and symptoms, restore function, reduce disability, and prevent progression; they should be offered to all patients with a confirmed diagnosis of migraine.1 Effective...