Skip to main content
Dawood Darbar on Muck Rack

Dawood Darbar

As seen in: Nature, SAGE Publishing, Science Magazine
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Dawood

Contact Dawood, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Gene-gene interactions between a LMNA variant and common polymorphisms drive early-onset atrial fibrillation

|
By Hanna Chen, Hammad farooq, Prisca K. Thami, Kathryn A. McGurk, George Powell, Jaime DeSantiago, Arvind Sridhar, Gregory Webster, Bradley J. Merrill, James Ware, Fu Siong Ng, Dawood Darbar, Asia Owais, Talla Abbas, Arif Pavel
| Nature Verified
Abstract Atrial fibrillation (AF), the most common sustained arrhythmia, has a complex genetic basis; however, the molecular mechanisms linking rare and common variants remain poorly understood. Polygenic risk score (PRS) analysis in the UK Biobank and All of Us cohorts reveals that carriers of protein-altering LMNA variants (PAVs) have a significantly higher risk of incident AF than predicted by PRS alone, supporting an additive effect of common polymorphisms and LMNA variants.
Open in Who Shared Issue with article?

Sample size determination for adaptive crossover trial in detecting gene-drug interactions

|
By Chen HY, Hua Chen, Dawood Darbar
| ncbi.nlm.nih.gov
Skip to main page content Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Save citation to file Format: Add to My Bibliography Your saved search Name of saved search: Search terms: Frequency: Which day? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Create a file for external citation management software doi: 10.1177/09622802231181704. Online ahead of print.
Open in Who Shared Issue with article?

Sample size determination for adaptive crossover trial in detecting gene-drug interactions

|
By Hua Chen, Dawood Darbar
| SAGE Publishing
Abstract Parallel design and crossover design are two of the most frequently used designs for studying drug-gene interactions. Due to the concerns of statistical power and ethics, it is often more prudent to use the crossover design while allowing the patients to have choices of not switching the treatment if the first stage treatment is effective. This complicates the calculation of the required sample size to achieve pre-specified statistical power.
Open in Who Shared Issue with article?
See all 6 articles