Daniel Brogan

Cite Jump to ExpandCollapse Research ArticleNovember 7, 2025 CTRL Enables Gene-Specific RNA Regulation Using CRISPR-Cas7–11 Click to copy article linkArticle link copied! Tianqi Wang Tianqi Wang School of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, United States Daniel J. Brogan Daniel J.

Lots of people are scared to ride their bikes in cities, where streets are busy and drivers distracted. Or at least that’s the perception held by as many as 60 percent of urban residents across the country who say speeding cars, buses, and trucks keep them from riding more—or at all, according to Avi Stopper, the founder of Bike Streets.

Abstract Type III-E CRISPR-Cas effectors, of which Cas7-11 is the first, are single proteins that cleave target RNAs without nonspecific collateral cleavage, opening new possibilities for RNA editing. Biochemical experiments combined with amide hydrogen-deuterium exchange (HDX-MS) experiments provide a first glimpse of the conformational dynamics of apo Cas7-11.