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Abstract To investigate the correlation between the thoracic transverse diameter/anteroposterior diameter (TTD/ATD) ratio and diaphragmatic excursion during deep breathing (DE-DB) in patients with chronic obstructive pulmonary disease (COPD), to evaluate their predictive value for lung function impairment, and to elucidate the underlying mechanism and clinical utility using mediation and decision curve analysis (DCA).
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Izquierdo M, Lin D, O’Neill S, Webster LA, Paterson C, Thomas J, et al. (2024) Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity. PLoS Negl Trop Dis 18(2): e0011956. https://doi.org/10.1371/journal.pntd.0011956 Editor: Igor C.
Abstract CD44, a cell surface adhesion receptor and stem cell biomarker, is recently implicated in chronic metabolic diseases. Ablation of CD44 ameliorates adipose tissue inflammation and insulin resistance in obesity. Here, we investigated cell type specific CD44 expression in human and mouse adipose tissue and further studied how CD44 in preadipocytes regulates adipocyte function.
Abstract Pan Assay INterference compoundS (PAINS) are known to be a source of false positives in High Throughput Screening (HTS) campaigns. This has become a major problem in medicinal chemistry, often resulting in undesirable project outcomes and increased overall cost. Our recent campaign to identify inhibitors of USP8 that could be used in the treatment of Parkinsons disease identified several PAINS that worked via a variety of mechanisms.
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