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Denise Barrett on Muck Rack

Denise Barrett

As seen in: BioRxiv
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Articles

The Quest to Identify USP8 Inhibitors for Parkinsons Disease, a PAINful Experience.

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By Stuart Lang, Denise Barrett, Fiona Bellany, De Lin
| BioRxiv
Abstract Pan Assay INterference compoundS (PAINS) are known to be a source of false positives in High Throughput Screening (HTS) campaigns. This has become a major problem in medicinal chemistry, often resulting in undesirable project outcomes and increased overall cost. Our recent campaign to identify inhibitors of USP8 that could be used in the treatment of Parkinsons disease identified several PAINS that worked via a variety of mechanisms.
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