de Medeiros Rimkus

Research Article Open Accessclass of evidencepodcast Related Podcast Introduction Myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD) is distinct from multiple sclerosis (MS),1 but their clinical and radiologic differentiation remains challenging.

Research Article Open Accessclass of evidence Introduction Myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD) is distinct from multiple sclerosis (MS),1 but their clinical and radiologic differentiation remains challenging.

Abstract The presence of diffuse brain damage in normal-appearing white matter (NAWM) and gray matter (NAGM) in neuromyelitis optica spectrum disorder (NMOSD) remains controversial. We aimed to address this controversy by applying a multiparametric MRI approach. Additionally, the association between MRI metrics and clinical variables was explored. In this cross-sectional study, we prospectively evaluated aquaporin-4-IgG positive NMOSD patients and healthy controls (HC) matched for age and sex.