De-Rui Zhao

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Carba-NAD binding activates SIR2 by reshaping conformational plasticity and rewiring long-range allosteric networks

Feb 20, 2026 |

By Meng-Ting Liu, Bao-Dan Zhang, De-Rui Zhao

| PLOS

Loading metrics Open Access Peer-reviewed Research Article Citation: Zhang B-D, Zhao D-R, Liu M-T, Yang L-Q, Sang P (2026) Carba-NAD binding activates SIR2 by reshaping conformational plasticity and rewiring long-range allosteric networks. PLoS Comput Biol 22(2): e1013966.

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De-Rui Zhao

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Carba-NAD binding activates SIR2 by reshaping conformational plasticity and rewiring long-range allosteric networks

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