Dea Mariette Mueller

Abstract Lytic bacteriophages (phage), viral predators of bacteria, offer a promising solution for treating bacterial infections. However, the narrow host range of phages limits the broad utility of individual phages, making the determinants of phage host range a subject of great interest.

Abstract As antimicrobial-resistant pathogens, particularly the rapidly mutating and adapting Pseudomonas aeruginosa, claim millions of lives worldwide each year, the development of novel therapeutic approaches becomes increasingly important. Bacteriophages (phages), viral predators of bacteria, represent a promising solution to fight bacterial infections. However, persistent challenges hinder the widespread application of phage therapy.