Deanna Necula

Abstract The full impact of APOE4 (apolipoprotein E4), the strongest genetic risk factor for Alzheimer’s disease (AD), on neuronal and network function remains unclear, particularly during early preclinical stages of disease. Here we show that young APOE4 knockin (E4-KI) mice exhibit hippocampal region-specific network hyperexcitability that predicts later cognitive deficits.

UCLA physicians confirmed the efficacy of an unconventional therapy for prostate cancer that significantly reduces the number of required radiotherapy treatments. In a study published in early February, researchers revealed shorter radiotherapy treatment was just as effective as traditional long-course therapy and created no additional side effects. Researchers pooled data from a large number of individual patients from different institutions who underwent the modified treatment plan.