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Deanna Zhu on Muck Rack

Deanna Zhu

As seen in: BioRxiv, eLife
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Articles

Stabilized dengue virus 2 envelope subunit vaccine redirects the neutralizing antibody response to all E-domains

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By Thanh Phan, Deanna Zhu, Devina Josephine Thiono, Demetrios Leonard Samaras
| BioRxiv
Abstract The four dengue virus (DENV) serotypes cause several hundred million infections annually. Several live-attenuated tetravalent dengue vaccines (LAVs) are at different stages of clinical testing and regulatory approval. A major hurdle faced by the two leading LAVs is uneven replication of vaccine serotypes stimulating a dominant response to one serotype at the expense of the other three which could lead to an increased likelihood of severe dengue.
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Evolution of a functionally intact but antigenically distinct DENV fusion loop

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By Rita M. Meganck, Deanna Zhu, Stephanie Dong, Lisa J Snoderly-Foster
| eLife
eLife assessment This valuable study describes engineered dengue virus variants that can be used to dissect epitope specificities in polyclonal sera, and to design candidate vaccine antigens that dampen antibody responses against undesirable epitopes. While the major claims are supported by solid evidence, experiments to distinguish the impact on antibody binding from neutralizing activities would have strengthened the study.
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Evolution of a Functionally Intact but Antigenically Distinct DENV Fusion Loop

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By Rita M. Meganck, Deanna Zhu, Stephanie Dong, Lisa J Snoderly-Foster
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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