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Debarpan Dhar

As seen in: PLOS, BioRxiv
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Articles

Sequences at gene segment termini inclusive of untranslated regions and partial open reading frames play a critical role in mammalian orthoreovirus S gene packaging

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By Debarpan Dhar, Samir Mehanovic, Walter Moss, Cathy Miller, PLOS Pathogens
| PLOS
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Dhar D, Mehanovic S, Moss W, Miller CL (2024) Sequences at gene segment termini inclusive of untranslated regions and partial open reading frames play a critical role in mammalian orthoreovirus S gene packaging. PLoS Pathog 20(2): e1012037. https://doi.org/10.1371/journal.ppat.1012037 Editor: Anice C.
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Sequences at gene segment termini inclusive of untranslated regions and partial open reading frames play a critical role in mammalian orthoreovirus S gene packaging

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By Samir Mehanovic, Walter Moss, Cathy Miller, Debarpan Dhar
| BioRxiv
Abstract Mammalian orthoreovirus (MRV) is a prototypic member of the Spinareoviridae family and has ten double-stranded RNA segments. One copy of each segment must be faithfully packaged into the mature virion, and prior literature suggests that nucleotides (nts) at the terminal ends of each gene likely facilitate their packaging. However, little is known about the precise packaging sequences required or how the packaging process is coordinated.
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