Debarya Saha on Muck Rack

Debarya Saha

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Articles

Uncoupling of mTORC1 from E2F activity maintains DNA damage and senescence - Nature Communications

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By Katherine R Ferrick, Debarya Saha
| Nature Verified
Abstract DNA damage is a primary trigger for cellular senescence, which in turn causes organismal aging and is a promising target of anti-aging therapies. Most DNA damage occurs when DNA is fragile during DNA replication in S phase, but senescent cells maintain DNA damage long-after DNA replication has stopped. How senescent cells induce DNA damage and why senescent cells fail to repair damaged DNA remain open questions.
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