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Articles by Debasis Pore
Withdrawal: Outer membrane protein A (OmpA) of Shigella flexneri 2a links innate and adaptive immunity in a TLR2-dependent manner and involvement of IL-12 and nitric oxide.
VOLUME 287 (2012) PAGES 12589–12601 This article has been withdrawn by the authors. Several concerns were raised. In Fig. 2A, the first two lanes of the GAPDH panel from BALB/c macrophages were rotated 180° and used in the last two lanes. Additionally, the first two lanes of the GAPDH panel from RAW macrophages were reused in the last two lanes. Finally, the iNOS panel from RAW macrophages was spliced. In Fig.
Cutting Edge: Deletion of Ezrin in B Cells of Lyn-Deficient Mice Downregulates Lupus Pathology
Cutting Edge: Deletion of Ezrin in B Cells of Lyn-Deficient Mice Downregulates Lupus Pathology Debasis Pore, Emily Huang, Dina Dejanovic, Neetha Parameswaran, Michael B. Cheung, Neetu Gupta The Journal of Immunology September 1, 2018, 201 (5) 1353-1358; DOI: 10.4049/jimmunol.1800168
Cutting Edge: Deletion of Ezrin in B Cells of Lyn-Deficient Mice Downregulates Lupus Pathology
Cutting Edge: Deletion of Ezrin in B Cells of Lyn-Deficient Mice Downregulates Lupus Pathology Debasis Pore, Emily Huang, Dina Dejanovic, Neetha Parameswaran, Michael B. Cheung, Neetu Gupta The Journal of Immunology July 18, 2018, ji1800168; DOI: 10.4049/jimmunol.1800168
Ezrin regulates inflammation by limiting B cell interleukin-10 production
In addition to their essential role in antibody production, B cells regulate immune responses by secreting effector cytokines. Interleukin 10 (IL-10) produced by B cells is important for controlling inflammation and autoimmunity, underscoring the importance of identifying mechanisms regulating B cell IL-10 production. We have previously demonstrated that the membrane-cytoskeleton linker protein ezrin regulates B cell antigen receptor organization and signaling.
Identification of Ezrin-Radixin-Moesin proteins as novel regulators of pathogenic B-cell receptor signaling and tumor growth in diffuse large B cell lymphoma
Diffuse large B cell lymphoma (DLBCL) is a hematological cancer associated with an aggressive clinical course. The predominant subtypes of DLBCL display features of chronic or tonic B cell antigen receptor (BCR) signaling. However, it is not known if the spatial organization of the BCR contributes to regulation of pro-survival signaling pathways and cell growth.
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