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Deborah Bourc’his

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Articles by Deborah Bourc’his

Simultaneous single-cell profiling of chromatin, transcriptome and surface markers with OneCell CUT&Tag captures epigenomic reprogramming

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By Anna Schwager, Eve Moutaux, Adeline Durand, Alexandra Van Keymeulen, Melanie Miranda, Simon Besson-Girard, Délia Dupré, Melissa Saichi, Simon Dumas, Mathias Schwartz, Justine Marsolier, Manuel Guthmann, Urvashi Chitnavis, Deborah Bourc’his, Elisabetta Marangoni, Nicolas Servant, Cédric Blanpain, Leïla Perié, Céline Vallot, Amélie Viaene, Marion Lambault, Grégoire Jouault, Juliette Bertorello, Marthe Laisné, Lorraine Bonneville
| Nature Verified
Abstract Simultaneous mapping of chromatin states and transcriptomes in rare cell populations is challenging, as most methods require thousands of cells and are limited in their ability to capture multiple molecular layers accurately within the same cell.
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UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells - Nature Communications

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By Michael Dumas, Deborah Bourc’his, Ambre Bender, Norbert B. Ghyselinck
| Nature Verified
Abstract In mammals, primordial germ cells (PGCs) undergo global erasure of DNA methylation with delayed demethylation of germline genes and selective retention of DNA methylation at evolutionarily young retrotransposons. However, the molecular mechanisms of persistent DNA methylation in PGCs remain unclear. Here we report that resistance to DNA methylation reprogramming in PGCs requires UHRF2, the paralog of the DNMT1 cofactor UHRF1.
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DNMT3A-dependent DNA methylation is required for spermatogonial stem cells to commit to spermatogenesis - Nature Genetics

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By Joan Barau, Michael Weber, Deborah Bourc’his, Mathieu Schulz
| Nature Verified
Abstract DNA methylation plays a critical role in spermatogenesis, as evidenced by the male sterility of DNA methyltransferase (DNMT) mutant mice. Here, we report a division of labor in the establishment of the methylation landscape of male germ cells and its functions in spermatogenesis.
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m 6 A RNA methylation regulates the fate of endogenous retroviruses

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By Sofia Rucli, Francois Dossin, Deborah Bourc’his, Tomasz Chelmicki
| Nature Verified
Abstract Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that affect genome regulation and cell physiology throughout their RNA-centred life cycle1. Failure to repress ERVs is associated with cancer, infertility, senescence and neurodegenerative diseases2,3.
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The diverse roles of DNA methylation in mammalian development and disease

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By Deborah Bourc’his
| Nature Verified
Abstract DNA methylation is of paramount importance for mammalian embryonic development. DNA methylation has numerous functions: it is implicated in the repression of transposons and genes, but is also associated with actively transcribed gene bodies and, in some cases, with gene activation per se. In recent years, sensitive technologies have been developed that allow the interrogation of DNA methylation patterns from a small number of cells.
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A single-cell chromatin map of human embryos

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By Raquel Pérez-Palacios, Deborah Bourc’his
| Nature Verified
The transition from a fertilized egg to a pluripotent and transcriptionally independent embryo requires multi-layered chromatin regulation. A study now provides simultaneous profiling of chromatin accessibility and DNA methylation in human preimplantation embryos at single-cell resolution.
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