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Joan Barau on Muck Rack

Joan Barau

As seen in: Nature, Science Magazine
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Articles

DNMT3A-dependent DNA methylation is required for spermatogonial stem cells to commit to spermatogenesis - Nature Genetics

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By Joan Barau, Michael Weber, Deborah Bourc’his, Mathieu Schulz
| Nature Verified
Abstract DNA methylation plays a critical role in spermatogenesis, as evidenced by the male sterility of DNA methyltransferase (DNMT) mutant mice. Here, we report a division of labor in the establishment of the methylation landscape of male germ cells and its functions in spermatogenesis.
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The DNA methyltransferase DNMT3C protects male germ cells from transposon activity

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By Joan Barau, Aurélie Teissandier
| Science Magazine Verified
DNA methylation plays an important role in repressing the expression of “parasitic” DNAs, such as transposable elements, which have invaded our genomes. Mammals have three DNA methyltransferase enzymes. Barau et al. discovered a fourth DNA methyltransferase enzyme in mice. The enzyme DNMT3C is a duplication of DNMT3B and is found in male germ cells. There it targets evolutionarily young transposons, of which there is a heavy burden in the mouse genome.
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