Deborah Muoio

Abstract Heart failure with preserved ejection fraction (HFpEF) and metabolic dysfunction-associated steatotic liver disease (MASLD) are increasingly prevalent, interrelated conditions driven by the global rise in obesity and metabolic syndrome. Once viewed in isolation, HFpEF and MASLD are now recognized as organ-specific manifestations of shared systemic metabolic dysfunction.

Abstract The constant expansion of the field of metabolic research has led to more nuanced and sophisticated understanding of the complex mechanisms that underlie metabolic functions and diseases. Collaborations with scientists of various fields such as neuroscience, immunology and drug discovery have further enhanced the ability to probe the role of metabolism in physiological processes.

1Cardiovascular and Metabolic Diseases, Duke-NUS Medical School, Singapore, Singapore 2Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA 3Department of Biochemistry and Pharmacology, The Bio21 Molecular Science & Biotechnology Institute, University of Melbourne, Melbourne, VIC, Australia 4Functional Proteomics, Institute of Cardiovascular Physiology, Goethe University, Frankfurt am Main, Germany 5Duke Molecular Physiology Institute, Duke University,...