Deerada Wijayatunga on Muck Rack

Deerada Wijayatunga

As seen in: BioRxiv
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Articles

ESCRT recruitment to damaged lysosomes is dependent on the ATG8 E3-like ligases

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By Dale Corkery, Shuang Li, Laura Herzog, Deerada Wijayatunga
| BioRxiv
Abstract The endosomal sorting complex required for transport (ESCRT) machinery plays an essential role in the sealing of endolysosomal membranes damaged by pathogenic, chemical or physical stress. How membrane damage is sensed by the cell and then translated into the recruitment of the ESCRT machinery is largely unknown. Here, we show that damage-dependent translocation of the autophagy ATG8 E3-like ligases to lysosomal membranes acts as the catalyst for ESCRT recruitment.
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