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Deivi Barci on Muck Rack

Deivi Barci

As seen in: Cell Reports Medicine
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Articles

Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling

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By Byrne C.J, Edyta Motta, Jiying Cheng, Deivi Barci
| Cell Reports Medicine Verified
Highlights • Interaction of myeloid and tumor (GBM) cells induces humanin expression • GBMs segregate inter-individually into humanin-sensitive or humanin-insensitive tumors • In sensitive GBMs, humanin induces cell-autonomous and systemic chemoresistance • Humanin-mediated therapy resistance can be addressed with clinically approved drugs Summary The DNA damage response (DDR) and the blood-tumor barrier (BTB) restrict chemotherapeutic success for primary brain tumors like glioblastomas (GBMs).
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