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Exploratory plasma ctDNA genomic biomarkers identified by whole-exome sequencing and a novel bioinformatics pipeline in advanced driver-negative NSCLC.
Posado-Domínguez, L. et al. (2026) Exploratory plasma ctDNA genomic biomarkers identified by whole-exome sequencing and a novel bioinformatics pipeline in advanced driver-negative NSCLC. Scientific Reports, (doi: 10.1038/s41598-026-55868-0) (PMID:42218277) Text 388758.pdf - Published Version Available under License Creative Commons Attribution.
ctDNA-derived copy-number signatures associated with immune checkpoint inhibitor resistance beyond PD-L1 and TMB in advanced NSCLC
Abstract Background: Immune checkpoint inhibitors (ICIs) have improved outcomes in advanced non-small cell lung cancer (NSCLC), but clinical benefit remains heterogeneous and is not fully explained by programmed death-ligand 1 (PD-L1) expression or tumour mutational burden (TMB). We explored whether whole-exome sequencing (WES) of circulating tumour DNA (ctDNA) could identify mutational and copy-number (CN) signatures associated with outcome in advanced NSCLC treated with first-line ICI.
Estrategias terapéuticas y pronósticas en el cáncer de pulmón no microcítico avanzado: impacto de la inmunoterapia, los biomarcadores y los cuidados paliativos en la práctica clínica real
Estrategias terapéuticas y pronósticas en el cáncer de pulmón no microcítico avanzado: impacto de la inmunoterapia, los biomarcadores y los cuidados paliativos en la práctica clínica real Luis Posado Domínguez 2025 Directores: Prof. Dr. Edel del Barco Morillo Dr. Alejandro Olivares Hernández Tutor: Prof.
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