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Deling Yin on Muck Rack

Deling Yin

As seen in: Nature, The Journal of Immunology
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Articles

Cardiomyocyte-derived GPX4 stabilizes BNIP3 to facilitate mitophagy and mitigate myocardial ischemia/reperfusion injury

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By Lingfeng Zhong, Zhenfeng Cheng, Yucong Zhang, Xiaoxi Fan, Yixin Zhou, Fan Yu, Ruihan Zheng, Derong Chen, Keke Ye, Jiahui Lin, Xi Chen, Zhouqing Huang, Chan Chen, Deling Yin, Weijian Huang, Bozhi Ye
| Nature Verified
Abstract GPX4 is a crucial regulator of ferroptosis, yet its role in mitochondrial dysfunction during myocardial ischemia/reperfusion injury (MI/RI) is unclear. This study aims to clarify the effect and molecular mechanisms of GPX4 in MI/RI. We analyzed the spatiotemporal dynamics of GPX4 during MI/RI and observed high expression levels in border and normal areas but a significant reduction in the ischemic region utilizing spatial transcriptomics, spatial proteomics, and single-cell sequencing.
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Beta-arrestin 2 plays a critical role in sepsis-induced cardiac dysfunction

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By Hui Li, Christopher Daniels, Deling Yin, Hui Yan, Krishna Singh Verified
| The Journal of Immunology Verified
Sepsis, a major clinical problem with high morbidity and mortality, is caused by overwhelming systemic host-inflammatory response. β-arrestin 2, a key regulator and scaffolds of various signaling, modulates cell survival and cell death in various systems. However, the effect of β-arrestin 2 on sepsis-induced cardiac dysfunction is not yet known. Here, we show that β-arrestin 2 overexpression significantly enhances animal survival following cecal ligation and puncture (CLP)-induced sepsis.
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