Delmis E Hernandez on Muck Rack

Delmis E Hernandez

As seen in: ACS Publications, Royal Society of Chemistry, Bioanalysis
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Articles

Transformation of a Potent C9-Substituted Phenylmorphan into MOR Partial Agonists with Improvement of Metabolic Stability: An In Vitro, In Vivo, and In Silico Study

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By Delmis E Hernandez, Dan Luo, Thomas E. Prisinzano, S. Stevens Negus
| ACS Publications
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Orally Bioavailable STING Antagonist Synthesized via Multi-component Povarov-Doebner Type Reaction

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By Delmis E Hernandez, Herman O Sintim, Jyotrimayee Samal
| Royal Society of Chemistry Verified
Orally Bioavailable STING Antagonist Synthesized via Multi-component Povarov-Doebner Type Reaction The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling has emerged as the major DNA-sensing pathway and one of the most prominent defensive mechanism in mammals.
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Dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations potently inhibits acute myeloid leukemia cell lines

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By Neetu Dayal, Clement Opoku-Temeng, Delmis E Hernandez, Moloud Aflaki Sooreshjani
| Bioanalysis Verified
Aim: Approximately 30% of acute myeloid leukemia (AML) patients carry FLT3 tyrosine kinase domain (TKD) mutations or internal tandem duplication (FLT3-ITD). Currently there is a paucity of compounds that are active against drug-resistant FLT3-ITD, which contains secondary mutations in the TKD, mainly at residues D835/F691. Results: HSD1169, a novel compound, is active against FLT3-ITD (D835 or F691).
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