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Demi A. Sandel

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Deciphering the immunopeptidome in vivo reveals new tumour antigens - Nature

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By Lauren Stopfer, Ryuhjin Ahn, William A. Freed-Pastor, Alex K. Shalek, Stefani Spranger, Tyler Jacks, Demi A. Sandel
| Nature Verified
Abstract Immunosurveillance of cancer requires the presentation of peptide antigens on major histocompatibility complex class I (MHC-I) molecules1,2,3,4,5. Current approaches to profiling of MHC-I-associated peptides, collectively known as the immunopeptidome, are limited to in vitro investigation or bulk tumour lysates, which limits our understanding of cancer-specific patterns of antigen presentation in vivo6.
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