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Demonta D. Coleman

As seen in: Nature
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Articles

Site-Specific Immobilization of ZNRF3 Reveals the Importance of Target Structural Integrity on Macrocyclic Peptide Selections Click to copy article link Article link copied!

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By Demonta D. Coleman, Linnette Arceo, Armita Paydar
| dx.doi.org
Introduction Click to copy section linkSection link copied! Macrocyclic peptide libraries displayed on filamentous phage have emerged as fertile sources of high-affinity ligands for challenging protein targets. (1,2) Although downstream hit-to-lead optimization is now routine, the earliest step in any biopanning campaign─the way in which a protein target is immobilized on a solid support─remains poorly examined.
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From nicotine to SARS-CoV-2 antivirals with potent in vivo efficacy and a broad anti-coronavirus spectrum - Nature Communications

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By Kaustav Khatua, Sandeep Atla, Demonta D. Coleman, Lauren Blankenship Verified, Yugendar R. Alugubelli, Veerabhadra Vulupala, Xuejiao Guo, Hongjie Xia, Birte Kalveram, David Walker, Brett Hurst, Sathish Kumar, Chia-Chuan Cho, Shivangi sharma Verified, Kai Yang, Satyanarayana Nyalata, Benjamin W. Neuman, Xuping Xie, Shiqing Xu, Wenshe Ray Liu, Dorsa Rabie
| Nature Verified
Abstract Anecdotal reports about smoking that might prevent SARS-CoV-2 infection inspire the search for nicotine and its pyrolysis products as inhibitors of the SARS-CoV-2 main protease (MPro). This effort leads to the discovery of 3-vinylpyridine as an MPro inhibitor. 3-Vinylpyridine resembles part of nirmatrelvir in binding to MPro but does not involve a critical interaction with residue E166, whose mutation has led to resistance to nirmatrelvir.
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