Dengmiao Xie on Muck Rack

Dengmiao Xie

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Articles

Catalytic and regulatory basis of tRNA t 6 A modification by the KEOPS complex

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By Li Zhou , Zelin Zhang, Mengqi Jin, Eric Westhof, Dongsheng Lei, Wenhua Zhang, Dengmiao Xie
| Nature
Abstract N6-threonylcarbamoyladenosine (t6A) at tRNA position 37 is essential for translational fidelity and cellular homeostasis. The multi-subunit KEOPS complex catalyzes t6A formation in Archaea and Eukarya. Here we present cryo-EM structures of C. elegans KEOPS in its apo and tRNA-bound states. tRNA binding induces concerted conformational rearrangements, distorting the anticodon loop to project A37 into the Kae1 active site. Kae1 recognizes the conserved G10–C25 pair and 36-UAA-38 motif.
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