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Denis Baronas on Muck Rack

Denis Baronas

As seen in: Science Magazine, BioRxiv
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Articles

High-throughput single cell omics using semipermeable capsules

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By State-independent ionic conductivityBy, J. Elaine Barclay, Wenhui Qiu, Denis Baronas
| Science Magazine Verified
Abstract Biological systems are inherently complex and heterogeneous. Deciphering this complexity increasingly relies on high-throughput single-cell omics methods and tools that efficiently probe the cellular phenotype and genotype.
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Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX

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By Janis Leitans, Aivaras Vaskevicius, Denis Baronas, Agne Kvietkauskaite
| BioRxiv
Abstract The CA IX is a transmembrane protein, highly overexpressed in hypoxic solid tumors, important for cancer cell survival and proliferation because it acidifies tumor microenvironment helping invasion and metastases processes. We designed novel compounds that have several functionalities: 1) primary sulfonamide group recognizing carbonic anhydrases (CA), 2) high-affinity moieties specifically recognizing CA IX among all CA isozymes, and 3) forming a covalent bond with the His64 residue.
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