Denis Martin Schewe on Muck Rack

Denis Martin Schewe

As seen in: Nature
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Articles

A quiescence/TGF-β1 CRISPRi screen reveals drug uptake transporters as secondary targets of kinase inhibitors in AML

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By Denis Martin Schewe
| tu-dresden.de
A quiescence/TGF-β1 CRISPRi screen reveals drug uptake transporters as secondary targets of kinase inhibitors in AML Research output: Contribution to journal › Review article › Contributed › peer-review
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Isocitrate dehydrogenase 1 mutation drives leukemogenesis by PDGFRA activation due to insulator disruption in acute myeloid leukemia (AML) - Leukemia

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By Lennart Lenk, Sonja Hänzelmann, Lorenz Bastian, Denis Martin Schewe, Veronica Yumiceba
| Nature
Cell culture KG1a myeloid leukemia cells contain a FGFR1OP2-FGFR1 gene fusion but lack other known driver mutations or genetic alterations and were therefore selected as cellular model. Cells were obtained from the German Collection of Microorganisms and Cell Cultures (DSMZ, Braunschweig, Germany), maintained at 0.2–2.0 million cells/ml in RPMI-1640 culture medium (Gibco, Billings, MT, United States) with 20% fetal bovine serum and checked regularly for mycoplasma.
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