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Denis Noble

As seen in: MSN UK, Color Research & Application, Nature, Wiley Online Library, Metro (UK), Educational Studies, Flipboard, Genome Biology, HuffPost UK, Big Think and
Biologist, author, music. Author of The Music of Life musicoflife.co.uk
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Articles

How physiology solves the gene-centric impasse

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By Denis Noble, Reine Bourret
| Wiley Online Library Verified
1 INTRODUCTION In a previous article in Experimental Physiology on the principles of systems biology, we identified the gene-centric impasse (Noble & Bourret, 2026). We now explain how that impasse arose and how it can be circumvented by physiological identification of the causes and cures. This will be a closely argued article and readers may appreciate orientation on the arguments in the various sections and how they interact and support the overall conclusions.
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The principles of systems biology

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By Denis Noble, Reine Bourret
| Wiley Online Library Verified
1 INTRODUCTION It is nearly two decades since the Principles of Systems Biology were formulated in this journal as a tribute to the 19th Century systems biologist, Claude Bernard (Noble, 2008a). That article has accumulated over 300 citations in fields as widespread as mathematics, physics, engineering, computer science, social sciences and philosophy. It is particularly important to note the inclusion of engineering science, mathematics and computer science.
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The cardiac pacemakers: A paradigm of robustness in evolutionary biology

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By Denis Noble
| Wiley Online Library Verified
This short review article will explain what robustness in functional physiological control networks means, and what are its developmental functional and evolutionary implications. I will use pacemaker rhythm in the heart as my paradigm example, since that is the one whose robustness I understand best. It was first discovered, both experimentally and in detailed mathematical modelling, over 30 years ago (Noble et al., 1992).
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