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Denison Kuruvilla

As seen in: Wiley Online Library
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Articles

Exposure‐Response Relationships for Pralsetinib in Patients with RET‐Altered Thyroid Cancer or RET Fusion‐Positive Nonsmall Cell Lung Cancer

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By Nastya Kassir, David McDougall, Denison Kuruvilla, Sean Kim
| Wiley Online Library Verified
-Kinases activated by gene fusions represent an important class of oncogenes associated with both solid and hematopoietic malignancies. They are typically produced by chromosomal rearrangements, and their chimeric protein products often form ideal targets for the development of cancer drugs.
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Applying Natural Language Processing to ClinicalTrials.gov: mRNA cancer vaccine case study

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By Bianca Vora, Chloe Kim, Michael Wu, Denison Kuruvilla
| Wiley Online Library Verified
METHODS To demonstrate the utility of NLP and text mining, we present a use case where we implemented these methodologies as a scalable solution to search for, and extract information from, planned, ongoing, and completed clinical research studies related to mRNA cancer vaccines on ClinicalTrials.gov. To this end, we utilized the Linguamatics I2E NLP platform which provides text analytics solutions based on keyword searches.
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